| Metric | Oct 30, 2024 FY24 Q3 | Feb 12, 2025 FY24 Q4 | May 1, 2025 FY25 Q1 | Jul 31, 2025 FY25 Q2 | Oct 30, 2025 FY25 Q3 | Feb 6, 2026 FY25 Q4 | Apr 29, 2026 FY26 Q1 | Jul 29, 2026 FY26 Q2 |
|---|---|---|---|---|---|---|---|---|
| For FY2027 | ||||||||
| Transaction to be accretive to Non-GAAP diluted EPS (Apellis) | — | — | — | — | — | — | — | New“accretive to Non-GAAP diluted EPS” |
| Apellis transaction | — | — | — | — | — | — | New“expected to be accretive” | — |
| Apellis transaction accretion | — | — | — | — | — | — | New“expected to be accretive in 2027” | — |
| Transaction run rate synergies exiting 2027 | — | — | — | — | — | — | — | New“at least $250 million” |
| For FY2026 | ||||||||
| Total revenue | — | — | — | — | — | New“decline by a mid-single digit percentage for 2026 as compared to 2025” | Reiterated“decline by a mid-single digit percentage for 2026 as compared to 2025” | — |
| Total revenue | — | — | — | — | — | — | New“expected to decline by a mid-single digit percentage” | — |
| Total revenue growth | — | — | — | — | — | — | — | New“mid-single digit percentage” |
| Acquired IPR&D charges impact on Non-GAAP diluted EPS | — | — | — | — | — | — | New“approximately $1.00” | — |
| Gross margin percentage | — | — | — | — | — | New“roughly consistent year-over-year” | — | — |
| Gross margin percentage vs 2025 | — | — | — | — | — | — | New“roughly consistent year-over-year” | — |
| Non-GAAP diluted EPS | — | — | — | — | — | New“$15.25 to $16.25” | — | — |
| Non-GAAP Diluted EPS - Approximate impact from acquired IPR&D and milestone charges | — | — | — | — | — | — | — | New“~($3.00)” |
| Non-GAAP Diluted EPS - Expected dilution from the Apellis acquisition | — | — | — | — | — | — | — | New“~($0.85)” |
| Non-GAAP Diluted EPS - Reported | — | — | — | — | — | — | — | New“$12.00 to $13.00” |
| Non-GAAP Diluted EPS - Underlying | — | — | — | — | — | — | — | New“$15.85 to $16.85” |
| Non-GAAP diluted EPS impact from TJ Biopharma felzartamab Greater China deal | — | — | — | — | — | — | New“approximately $0.55” | — |
| Non-GAAP Diluted EPS Updated | — | — | — | — | — | — | New“$14.25 to $15.25” | — |
| Combined Non-GAAP R&D expense and Non-GAAP SG&A expense | — | — | — | — | — | — | — | New“between $2.65 billion and $2.70 billion” |
| Combined Non-GAAP R&D expense and Non-GAAP SG&A expense vs 2025 | — | — | — | — | — | — | New“roughly consistent year-over-year” | — |
| Impact from acquired IPR&D charges expected in second quarter 2026 | — | — | — | — | — | — | New“approximately $0.80” | — |
| Non-GAAP effective tax rate | — | — | — | — | — | — | New“between approximately 17% and 18%” | — |
| Non-GAAP effective tax rate | — | — | — | — | — | New“between approximately 17% and 18%” | — | — |
| For FY2025 | ||||||||
| Contract manufacturing revenue | — | — | — | New“minimal” | — | — | — | — |
| Manufacturing revenue | — | — | — | — | New“between $10 million and $20 million” | — | — | — |
| Total revenue | — | New“expected to decline by a mid-single digit percentage for 2025 compared to 2024” | Revised“decline by a mid-single digit percentage” | — | Revised“approximately flat to increasing 1%, at constant currency” | — | — | — |
| Total revenue vs full year 2024 (constant currency) | — | — | — | New“approximately flat, at constant currency, versus full year 2024” | — | — | — | — |
| Total revenue, at constant currency, versus full year 2024 | — | — | — | — | New“approximately flat to increasing 1%” | — | — | — |
| Foreign exchange headwind on Non-GAAP diluted EPS | — | New“approximately $0.35” | — | — | — | — | — | — |
| Non-GAAP diluted EPS | — | New“$15.25 to $16.25” | — | — | — | — | — | — |
| Non-GAAP Diluted EPS - Approx. impact from BD transactions expected to close in Q4'25 | — | — | — | — | New“~($1.25)” | — | — | — |
| Non-GAAP Diluted EPS - Benefit from stronger business outlook | — | — | — | — | New“+$0.25” | — | — | — |
| Non-GAAP Diluted EPS - Prior (July 2025) | — | — | — | — | New“$15.50 to $16.00” | — | — | — |
| Non-GAAP Diluted EPS - Revised business outlook (October 2025) | — | — | — | — | New“$15.75 to $16.25” | — | — | — |
| Non-GAAP Diluted EPS - Updated | — | — | New“$14.50 to $15.50” | Raised“$15.50 to $16.00” | Lowered“$14.50 to $15.00” | — | — | — |
| Operating margin percentage | — | New“remain relatively flat” | — | — | — | — | — | — |
| Combined Non-GAAP R&D expense and Non-GAAP SG&A expense | — | — | — | — | New“approximately $1.1 billion” | — | — | — |
| Combined Non-GAAP R&D expense and Non-GAAP SG&A expense | — | New“approximately $3.9 billion” | Reiterated“approximately $3.9 billion” | Raised“approximately $4.0 billion” | — | — | — | — |
| Fit for Growth program gross savings | — | New“approximately $1 billion” | Reiterated“approximately $1 billion” | Reiterated“approximately $1 billion” | Reiterated“approximately $1 billion” | — | — | — |
| Fit for Growth program net savings | — | — | — | New“$800 million net of reinvestment” | — | — | — | — |
| Fit for Growth program net savings (net of reinvestment) | — | New“$800 million” | Reiterated“$800 million net of reinvestment” | — | Reiterated“$800 million” | — | — | — |
| Fit for Growth program savings | — | — | — | New“approximately $1 billion of gross savings and $800 million net of reinvestment” | — | — | — | — |
| For FY2024 | ||||||||
| Core pharmaceutical revenue | New“relatively flat for 2024 compared to 2023” | — | — | — | — | — | — | — |
| Cost of sales as a percentage of total revenue | New“an improvement in the cost of sales as a percentage of total revenue for 2024 compared to 2023 driven by product mix and significantly lower idle capacity charges” | — | — | — | — | — | — | — |
| Total revenue | New“full year 2024 total revenue decline of a low-single digit percentage versus full year 2023” | — | — | — | — | — | — | — |
| Non-GAAP diluted EPS | New“now expected to be between $16.10 and $16.60, representing Non-GAAP diluted EPS growth of approximately 11% at the mid-point versus full year 2023” | — | — | — | — | — | — | — |
| Operating income | New“operating income to grow at a high-teen percentage versus full year 2023” | — | — | — | — | — | — | — |
| Operating margin improvement | New“mid-single digit percentage operating margin improvement” | — | — | — | — | — | — | — |
| No period stated | ||||||||
| Non-GAAP Diluted EPS | — | — | — | — | — | — | New“$14.25 to $15.25” | — |