Gilead Sciences — Apr 24, 2025 release

EXHIBIT 99.1 Document GILEAD SCIENCES ANNOUNCES FIRST QUARTER 2025 FINANCIAL RESULTS Product Sales Excluding Veklury Increased 4% Year-Over-Year to $6.3 billion Biktarvy Sales Increased 7% Year-Over-Year to $3.1 billion Foster City, CA, April 24, 2025 - Gilead Sciences, Inc. (Nasdaq: GILD) announced today its first quarter 2025 results of operations. “Gilead had a strong start to the year driven by excellent commercial and clinical execution along with disciplined expense management,” said Daniel O’Day, Gilead’s Chairman and Chief Executive Officer. “Our base business grew 4% year-over-year, primarily led by Biktarvy’s continued strength, and we announced positive topline Phase 3 results for Trodelvy plus pembrolizumab in first line PD-L1+ metastatic triple negative breast cancer. With the upcoming June PDUFA date for lenacapavir for HIV prevention, and continued progress across our diverse pipeline, we look forward to building on our positive momentum throughout the year.” First Quarter 2025 Financial Results • Total first quarter 2025 revenue of $6.7 billion remained flat compared to the same period in 2024, with lower Veklury® (remdesivir) and Oncology sales offset by higher HIV and Liver Disease sales. • Diluted earnings (loss) per share (“EPS”) was $1.04 in the first quarter 2025 compared to $(3.34) in the same period in 2024. The increase was primarily driven by prior year charges that did not repeat, including the impact of a $3.9 billion acquired in-process research and development ("IPR&D") expense related to the acquisition of CymaBay Therapeutics, Inc. (“CymaBay”), as well as a pre-tax IPR&D impairment of $2.4 billion related to assets acquired by Gilead from Immunomedics, Inc. (“Immunomedics”) in 2020. This increase was partially offset by higher tax expense and higher net unrealized losses on equity investments in the first quarter 2025. • Non-GAAP diluted EPS was $1.81 in the first quarter 2025 compared to $(1.32) in the same period in 2024. The increase was primarily driven by the prior year IPR&D expense related to the CymaBay acquisition. • As of March 31, 2025, Gilead had $7.9 billion of cash and cash equivalents compared to $10.0 billion as of December 31, 2024. • During the first quarter 2025, Gilead generated $1.8 billion in operating cash flow. • During the first quarter 2025, Gilead paid dividends of $1.0 billion and repurchased $730 million of common stock. In addition, Gilead repaid $1.8 billion of Senior Notes in February 2025. First Quarter 2025 Product Sales Total first quarter 2025 product sales decreased 1% to $6.6 billion compared to the same period in 2024. Total first quarter 2025 product sales excluding Veklury increased 4% to $6.3 billion compared to the same period in 2024, primarily due to higher HIV and Liver Disease sales, partially offset by lower Oncology sales. HIV product sales increased 6% to $4.6 billion in the first quarter 2025 compared to the same period in 2024, primarily driven by higher average realized price and demand. • Biktarvy® (bictegravir 50mg/emtricitabine (“FTC”) 200mg/tenofovir alafenamide (“TAF”) 25mg) sales increased 7% to $3.1 billion in the first quarter 2025 compared to the same period in 2024, primarily driven by higher demand. April 24, 2025 2      • Descovy® (FTC 200mg/TAF 25mg) sales increased 38% to $586 million in the first quarter 2025 compared to the same period in 2024, primarily driven by higher average realized price and higher demand. The Liver Disease portfolio sales increased 3% to $758 million in the first quarter 2025 compared to the same period in 2024. This was primarily driven by increased demand in products for primary biliary cholangitis (“PBC”), chronic hepatitis B virus (“HBV”) and chronic hepatitis delta virus (“HDV”), partially offset by lower average realized price for chronic hepatitis C virus (“HCV”) products. Veklury sales decreased 45% to $302 million in the first quarter 2025 compared to the same period in 2024, primarily driven by lower rates of COVID-19 related hospitalizations across regions. Cell Therapy product sales decreased 3% to $464 million in the first quarter 2025 compared to the same period in 2024. • Yescarta® (axicabtagene ciloleucel) sales increased 2% to $386 million in the first quarter 2025 compared to the same period in 2024, primarily driven by higher average realized price and increased rest of world demand, partially offset by lower demand in the United States. • Tecartus® (brexucabtagene autoleucel) sales decreased 22% to $78 million in the first quarter 2025 compared to the same period in 2024, primarily reflecting lower demand in the United States. Trodelvy® (sacituzumab govitecan-hziy) sales decreased 5% to $293 million in the first quarter 2025 compared to the same period in 2024, primarily driven by inventory dynamics and lower average realized price, partially offset by higher demand. First Quarter 2025 Product Gross Margin, Operating Expenses and Effective Tax Rate • Product gross margin was 76.7% in the first quarter 2025 compared to 76.6% in the same period in 2024. Non-GAAP product gross margin was 85.5% in the first quarter 2025 compared to 85.4% in the same period in 2024. • Research and development (“R&D”) expenses were $1.4 billion in the first quarter 2025 compared to $1.5 billion in the same period in 2024, primarily due to lower clinical manufacturing activities and prior year CymaBay acquisition-related expenses that did not repeat. Non-GAAP R&D expenses were $1.3 billion in the first quarter 2025 compared to $1.4 billion in the same period in 2024, primarily due to lower clinical manufacturing activities. • Acquired IPR&D expenses were $253 million in the first quarter 2025, primarily reflecting expenses related to the strategic partnership with LEO Pharma A/S (“LEO Pharma”) announced in January 2025. • Selling, general and administrative (“SG&A”) expenses were $1.3 billion in the first quarter 2025 compared to $1.4 billion in the same period in 2024, primarily driven by prior year CymaBay acquisition-related expenses that did not repeat as well as lower corporate expenses, partially offset by incremental selling and marketing expenses in the United States. Non-GAAP SG&A expenses were $1.2 billion in the first quarter 2025 compared to $1.3 billion in the same period in 2024. This was primarily driven by lower corporate expenses, partially offset by incremental selling and marketing expenses in the United States. • The effective tax rate (“ETR”) was 20.2% in the first quarter 2025 compared to 7.0% in the same period in 2024, and the non-GAAP ETR was 16.3% in the first quarter 2025 compared to (29.8)% in the same period in 2024. These changes primarily reflect the prior year non-deductible acquired IPR&D charge related to the CymaBay acquisition, and higher tax benefits from stock-based compensation. April 24, 2025 3      Guidance and Outlook For the full-year, Gilead expects: (in millions, except per share amounts) April 24, 2025 Guidance Low End High End Comparison to Prior Guidance Product sales $ 28,200  $ 28,600  Unchanged Product sales excluding Veklury $ 26,800  $ 27,200  Unchanged Veklury $ 1,400  $ 1,400  Unchanged Diluted EPS $ 5.65  $ 6.05  Previously $5.95 to $6.35 Non-GAAP diluted EPS $ 7.70  $ 8.10  Unchanged Additional information and a reconciliation between GAAP and non-GAAP financial information for the 2025 guidance is provided in the accompanying tables. The financial guidance is subject to a number of risks and uncertainties. See the Forward-Looking Statements section below. Key Updates Since Our Last Quarterly Release Virology • Announced FDA accepted New Drug Application submissions for twice-yearly lenacapavir for HIV prevention under priority review, with a PDUFA date of June 19, 2025. • Announced the European Medicines Agency validated the Marketing Authorization Application and EU-Medicines for All application for twice-yearly lenacapavir for HIV prevention, which will undergo parallel reviews under an Accelerated Assessment timeline. • Presented initial Phase 1 data evaluating investigational once-yearly lenacapavir for HIV prevention at the Conference on Retroviruses and Opportunistic Infections (“CROI”), and announced plans to launch a Phase 3 study in the second half of 2025. • Presented HIV treatment research data at CROI, including long-term outcomes evaluating the use of Biktarvy in people with HIV/HBV coinfection and the primary results of a Phase 2 study evaluating the investigational combination regimen of lenacapavir and broadly neutralizing antibodies teropavimab and zinlirvimab. Oncology • Announced Trodelvy plus Keytruda® (pembrolizumab) demonstrated a statistically significant and clinically meaningful improvement in progression free survival in patients with previously untreated PD-L1+ unresectable locally advanced or metastatic triple-negative breast cancer in the Phase 3 ASCENT-04 trial. The use of Trodelvy plus Keytruda is investigational in this setting. Inflammation • Received conditional marketing authorization from the European Commission for seladelpar for the treatment of PBC in combination with ursodeoxycholic acid (“UDCA”) in adults who have an inadequate response to UDCA alone, or as monotherapy in those unable to tolerate UDCA. Corporate • The Board declared a quarterly dividend of $0.79 per share of common stock for the second quarter of 2025. The dividend is payable on June 27, 2025, to stockholders of record at the close of business on June 13, 2025. Future dividends will be subject to Board approval. Certain amounts and percentages in this press release may not sum or recalculate due to rounding. April 24, 2025 4      Conference Call At 1:30 p.m. Pacific Time today, Gilead will host a conference call to discuss Gilead’s results. A live webcast will be available on http://investors.gilead.com and will be archived on www.gilead.com for one year. Non-GAAP Financial Information The information presented in this document has been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”), unless otherwise noted as non-GAAP. Management believes non-GAAP information is useful for investors, when considered in conjunction with Gilead’s GAAP financial information, because management uses such information internally for its operating, budgeting and financial planning purposes. Non-GAAP information is not prepared under a comprehensive set of accounting rules and should only be used to supplement an understanding of Gilead’s operating results as reported under GAAP. Non-GAAP financial information generally excludes acquisition-related expenses including amortization of acquired intangible assets and other items that are considered unusual or not representative of underlying trends of Gilead’s business, fair value adjustments of equity securities and discrete and related tax charges or benefits associated with such exclusions as well as changes in tax-related laws and guidelines, transfers of intangible assets between certain legal entities, and legal entity restructurings. Although Gilead consistently excludes the amortization of acquired intangible assets from the non-GAAP financial information, management believes that it is important for investors to understand that such intangible assets were recorded as part of acquisitions and contribute to ongoing revenue generation. Non-GAAP measures may be defined and calculated differently by other companies in the same industry. Reconciliations of the non-GAAP financial measures to the most directly comparable GAAP financial measures are provided in the accompanying tables. About Gilead Sciences Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, COVID-19, cancer and inflammation. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California. Forward-Looking Statements Statements included in this press release that are not historical in nature are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Gilead cautions readers that forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include those relating to: Gilead’s ability to achieve its full year 2025 financial guidance, including as a result of the uncertainty of the amount and timing of Veklury revenues, the impact of the Inflation Reduction Act, changes in U.S. regulatory or legislative policies, and changes in U.S. trade policies, including tariffs; Gilead’s ability to make progress on any of its long-term ambitions or priorities laid out in its corporate strategy; Gilead’s ability to accelerate or sustain revenues for its virology, oncology and other programs; Gilead’s ability to realize the potential benefits of acquisitions, collaborations or licensing arrangements, including the acquisitions of CymaBay and Immunomedics, and the arrangement with LEO Pharma; patent protection and estimated loss of exclusivity for our products and product candidates; Gilead’s ability to initiate, progress or complete clinical trials within currently anticipated timeframes or at all, the possibility of unfavorable results from ongoing and additional clinical trials, including those involving Biktarvy, Trodelvy, lenacapavir, teropavimab and zinlirvimab, and the risk that safety and efficacy data from clinical trials may not warrant further development of Gilead’s product candidates or the product candidates of Gilead’s strategic partners; Gilead’s ability to submit new drug applications for new product candidates or expanded indications in the currently anticipated timelines, including for lenacapavir for HIV PrEP; Gilead’s ability to receive or maintain regulatory approvals in a timely manner or at all, including for lenacapavir for PrEP, and the risk that any such approvals, if granted, may be subject to significant limitations on use and may be subject to withdrawal or other adverse actions by the applicable regulatory authority; Gilead’s ability to successfully commercialize its products; the risk of potential disruptions to the manufacturing and supply chain of Gilead’s products; pricing and reimbursement pressures from government agencies and other third parties, April 24, 2025 5      including required rebates and other discounts; a larger than anticipated shift in payer mix to more highly discounted payer segments; market share and price erosion caused by the introduction of generic versions of Gilead products; the risk that physicians and patients may not see advantages of Gilead’s products over other therapies and may therefore be reluctant to prescribe the products, including Livdelzi/Lyvdelzi; and other risks identified from time to time in Gilead’s reports filed with the SEC, including annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K. In addition, Gilead makes estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses and related disclosures. Gilead bases its estimates on historical experience and on various other market specific and other relevant assumptions that it believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. There may be other factors of which Gilead is not currently aware that may affect matters discussed in the forward-looking statements and may also cause actual results to differ significantly from these estimates. Further, results for the quarter ended March 31, 2025 are not necessarily indicative of operating results for any future periods. Gilead directs readers to its press releases, annual reports on Form 10-K, quarterly reports on Form 10-Q and other subsequent disclosure documents filed with the SEC. Gilead claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. The reader is cautioned that forward-looking statements are not guarantees of future performance and is cautioned not to place undue reliance on these forward-looking statements. All forward-looking statements are based on information currently available to Gilead and Gilead assumes no obligation to update or supplement any such forward-looking statements other than as required by law. Any forward-looking statements speak only as of the date hereof or as of the dates indicated in the statements. Additional information is available on our Investor Relations website, https://investors.gilead.com. Among other things, an estimate of Acquired IPR&D expenses is expected to be made available on the Quarterly Results page within the first ten (10) days after the end of each quarter. # # # Gilead owns or has rights to various trademarks, copyrights and trade names used in its business, including the following: GILEAD®, GILEAD SCIENCES®, KITE TM , AMBISOME®, ATRIPLA®, BIKTARVY®, CAYSTON®, COMPLERA®, DESCOVY®, DESCOVY FOR PREP®, EMTRIVA®, EPCLUSA®, EVIPLERA®, GENVOYA®, HARVONI®, HEPCLUDEX®, HEPSERA®, JYSELECA®, LIVDELZI®/LYVDELZI®, LETAIRIS®, ODEFSEY®, SOVALDI®, STRIBILD®, SUNLENCA® , TECARTUS®, TRODELVY®, TRUVADA®, TRUVADA FOR PREP®, TYBOST®, VEKLURY®, VEMLIDY®, VIREAD®, VOSEVI®, YESCARTA® and ZYDELIG®. For more information on Gilead Sciences, Inc., please visit www.gilead.com or call the Gilead Public Affairs Department at 1-800-GILEAD-5 (1-800-445-3235). CONTACTS: Investors: Jacquie Ross, CFA investor_relations@gilead.com Media: Ashleigh Koss public_affairs@gilead.com April 24, 2025 6      GILEAD SCIENCES, INC. CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (unaudited) Three Months Ended March 31, (in millions, except per share amounts) 2025 2024 Revenues: Product sales $ 6,613  $ 6,647  Royalty, contract and other revenues 54  39  Total revenues 6,667  6,686  Costs and expenses: Cost of goods sold 1,540  1,552  Research and development expenses 1,379  1,520  Acquired in-process research and development expenses 253  4,131  In-process research and development impairments —  2,430  Selling, general and administrative expenses 1,258  1,375  Total costs and expenses 4,430  11,008  Operating income (loss) 2,237  (4,322) Interest expense 260  254  Other (income) expense, net 328  (91) Income (loss) before income taxes 1,649  (4,486) Income tax expense (benefit) 334  (315) Net income (loss) 1,315  (4,170) Net income attributable to noncontrolling interest —  —  Net income (loss) attributable to Gilead $ 1,315  $ (4,170) Basic earnings (loss) per share attributable to Gilead $ 1.06  $ (3.34) Diluted earnings (loss) per share attributable to Gilead $ 1.04  $ (3.34) Shares used in basic earnings (loss) per share attributable to Gilead calculation 1,246  1,247  Shares used in diluted earnings (loss) per share attributable to Gilead calculation 1,259  1,247  Supplemental Information: Cash dividends declared per share $ 0.79  $ 0.77  Product gross margin 76.7  % 76.6  % Research and development expenses as a % of revenues 20.7  % 22.7  % Selling, general and administrative expenses as a % of revenues 18.9  % 20.6  % Operating margin 33.6  % (64.6) % Effective tax rate 20.2  % 7.0  % April 24, 2025 7      GILEAD SCIENCES, INC. TOTAL REVENUE SUMMARY (unaudited) Three Months Ended March 31, (in millions, except percentages) 2025 2024 Change Product sales: HIV $ 4,587  $ 4,342  6% Liver Disease 758  737  3% Oncology 757  789  (4)% Other 209  224  (7)% Total product sales excluding Veklury 6,311  6,092  4% Veklury 302  555  (45)% Total product sales 6,613  6,647  (1)% Royalty, contract and other revenues 54  39  37% Total revenues $ 6,667  $ 6,686  —% April 24, 2025 8      GILEAD SCIENCES, INC. NON-GAAP FINANCIAL INFORMATION (1) (unaudited) Three Months Ended March 31, (in millions, except percentages) 2025 2024 Change Non-GAAP: Cost of goods sold $ 961  $ 974  (1)% Research and development expenses $ 1,338  $ 1,403  (5)% Acquired IPR&D expenses (2) $ 253  $ 4,131  (94)% Selling, general and administrative expenses $ 1,222  $ 1,295  (6)% Other (income) expense, net $ (98) $ (104) (6)% Diluted earnings (loss) per share attributable to Gilead $ 1.81  $ (1.32) NM Shares used in non-GAAP diluted earnings (loss) per share attributable to Gilead calculation 1,259  1,247  1% Product gross margin 85.5  % 85.4  % 12 bps Research and development expenses as a % of revenues 20.1  % 21.0  % -91 bps Selling, general and administrative expenses as a % of revenues 18.3  % 19.4  % -104 bps Operating margin 43.4  % (16.7) % NM Effective tax rate 16.3  % (29.8) % NM ________________________________ NM - Not Meaningful (1)     Refer to Non-GAAP Financial Information section above for further disclosures on non-GAAP financial measures. A reconciliation between GAAP and non-GAAP financial information is provided in the tables below. (2)     Equal to GAAP financial information. April 24, 2025 9      GILEAD SCIENCES, INC. RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL INFORMATION (unaudited) Three Months Ended March 31, (in millions, except percentages and per share amounts) 2025 2024 Cost of goods sold reconciliation: GAAP cost of goods sold $ 1,540  $ 1,552  Acquisition-related – amortization (1) (579) (579) Non-GAAP cost of goods sold $ 961  $ 974  Product gross margin reconciliation: GAAP product gross margin 76.7  % 76.6  % Acquisition-related – amortization (1) 8.8  % 8.7  % Non-GAAP product gross margin 85.5  % 85.4  % Research and development expenses reconciliation: GAAP research and development expenses $ 1,379  $ 1,520  Acquisition-related – other costs (2) (2) (66) Restructuring (38) (50) Non-GAAP research and development expenses $ 1,338  $ 1,403  IPR&D impairment reconciliation: GAAP IPR&D impairment $ —  $ 2,430  IPR&D impairment —  (2,430) Non-GAAP IPR&D impairment $ —  $ —  Selling, general and administrative expenses reconciliation: GAAP selling, general and administrative expenses $ 1,258  $ 1,375  Acquisition-related – other costs (2) —  (67) Restructuring (36) (13) Non-GAAP selling, general and administrative expenses $ 1,222  $ 1,295  Operating income (loss) reconciliation: GAAP operating income (loss) $ 2,237  $ (4,322) Acquisition-related – amortization (1) 579  579  Acquisition-related – other costs (2) 2  133  Restructuring 74  63  IPR&D impairment —  2,430  Non-GAAP operating income (loss) $ 2,893  $ (1,117) Operating margin reconciliation: GAAP operating margin 33.6  % (64.6) % Acquisition-related – amortization (1) 8.7  % 8.7  % Acquisition-related – other costs (2) —  % 2.0  % Restructuring 1.1  % 0.9  % IPR&D impairment —  % 36.3  % Non-GAAP operating margin 43.4  % (16.7) % Other (income) expense, net reconciliation: GAAP other (income) expense, net $ 328  $ (91) Loss from equity securities, net (426) (14) Non-GAAP other (income) expense, net $ (98) $ (104) Income (loss) before income taxes reconciliation: GAAP income (loss) before income taxes $ 1,649  $ (4,486) Acquisition-related – amortization (1) 579  579  Acquisition-related – other costs (2) 2  133  Restructuring 74  63  IPR&D impairment —  2,430  Loss from equity securities, net 426  14  Non-GAAP income (loss) before income taxes $ 2,731  $ (1,267) April 24, 2025 10      GILEAD SCIENCES, INC. RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL INFORMATION - (Continued) (unaudited) Three Months Ended March 31, (in millions, except percentages and per share amounts) 2025 2024 Income tax expense (benefit) reconciliation: GAAP income tax expense (benefit) $ 334  $ (315) Income tax effect of non-GAAP adjustments: Acquisition-related – amortization (1) 120  121  Acquisition-related – other costs (2) —  30  Restructuring 14  10  IPR&D impairment —  611  Loss (gain) from equity securities, net 20  (39) Discrete and related tax charges (3) (42) (39) Non-GAAP income tax expense $ 446  $ 379  Effective tax rate reconciliation: GAAP effective tax rate 20.2  % 7.0  % Income tax effect of above non-GAAP adjustments and discrete and related tax adjustments (3) (3.9) % (36.8) % Non-GAAP effective tax rate 16.3  % (29.8) % Net income (loss) attributable to Gilead reconciliation: GAAP net income (loss) attributable to Gilead $ 1,315  $ (4,170) Acquisition-related – amortization (1) 459  458  Acquisition-related – other costs (2) 2  103  Restructuring 61  54  IPR&D impairment —  1,819  Loss from equity securities, net 406  53  Discrete and related tax charges (3) 42  39  Non-GAAP net income (loss) attributable to Gilead $ 2,285  $ (1,644) Diluted earnings (loss) per share reconciliation: GAAP diluted earnings (loss) per share $ 1.04  $ (3.34) Acquisition-related – amortization (1) 0.36  0.37  Acquisition-related – other costs (2) —  0.08  Restructuring 0.05  0.04  IPR&D impairment —  1.46  Loss from equity securities, net 0.32  0.04  Discrete and related tax charges (3) 0.03  0.03  Non-GAAP diluted earnings (loss) per share $ 1.81  $ (1.32) Non-GAAP adjustment summary: Cost of goods sold adjustments $ 579  $ 579  Research and development expenses adjustments 40  117  IPR&D impairment adjustments —  2,430  Selling, general and administrative expenses adjustments 36  80  Total non-GAAP adjustments to costs and expenses 656  3,205  Other (income) expense, net, adjustments 426  14  Total non-GAAP adjustments before income taxes 1,082  3,219  Income tax effect of non-GAAP adjustments above (154) (732) Discrete and related tax charges (3) 42  39  Total non-GAAP adjustments to net income attributable to Gilead $ 970  $ 2,526  ________________________________ (1)     Relates to amortization of acquired intangibles. (2)     Adjustments include integration expenses and contingent consideration fair value adjustments associated with Gilead’s recent acquisitions. (3)     Represents discrete and related deferred tax charges or benefits primarily associated with acquired intangible assets and transfers of intangible assets from a foreign subsidiary to Ireland and the United States. April 24, 2025 11      GILEAD SCIENCES, INC. RECONCILIATION OF GAAP TO NON-GAAP 2025 FULL-YEAR GUIDANCE (1) (unaudited) (in millions, except percentages and per share amounts) Provided February 11, 2025 Updated April 24, 2025 Projected product gross margin GAAP to non-GAAP reconciliation: GAAP projected product gross margin 77.0% - 78.0% 77.0% - 78.0% Acquisition-related expenses ~ 8.0% ~ 8.0% Non-GAAP projected product gross margin 85.0% - 86.0% 85.0% - 86.0% Projected operating income GAAP to non-GAAP reconciliation: GAAP projected operating income $10,200 - $10,700 $10,200 - $10,700 Acquisition-related and restructuring expenses ~ 2,500 ~ 2,500 Non-GAAP projected operating income $12,700 - $13,200 $12,700 - $13,200 Projected effective tax rate GAAP to non-GAAP reconciliation: GAAP projected effective tax rate ~ 20% ~ 21% Income tax effect of above non-GAAP adjustments and fair value adjustments of equity securities, and discrete and related tax adjustments (~ 1%) (~ 2%) Non-GAAP projected effective tax rate ~ 19% ~ 19% Projected diluted EPS GAAP to non-GAAP reconciliation: GAAP projected diluted EPS $5.95 - $6.35 $5.65 - $6.05 Acquisition-related and restructuring expenses, fair value adjustments of equity securities and discrete and related tax adjustments ~ 1.75 ~ 2.05 Non-GAAP projected diluted EPS $7.70 - $8.10 $7.70 - $8.10 ________________________________ (1)     Our full-year guidance excludes the potential impact of any (i) acquisitions or business development transactions that have not been executed, (ii) future fair value adjustments of equity securities and (iii) discrete tax charges or benefits associated with changes in tax related laws and guidelines that have not been enacted, as Gilead is unable to project such amounts. The non-GAAP full-year guidance includes non-GAAP adjustments to actual current period results as well as adjustments for the known future impact associated with events that have already occurred, such as future amortization of our intangible assets and the future impact of discrete and related deferred tax charges or benefits primarily associated with acquired intangible assets and in-process research and development, transfers of intangible assets from a foreign subsidiary to Ireland and the United States, and legal entity restructurings. April 24, 2025 12      GILEAD SCIENCES, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) March 31, December 31, (in millions) 2025 2024 Assets Cash and cash equivalents $ 7,926  $ 9,991  Accounts receivable, net 4,388  4,420  Inventories 3,778  3,589  Property, plant and equipment, net 5,421  5,414  Intangible assets, net 19,355  19,948  Goodwill 8,314  8,314  Other assets 7,253  7,319  Total assets $ 56,434  $ 58,995  Liabilities and Stockholders’ Equity Current liabilities $ 12,344  $ 12,004  Long-term liabilities 25,012  27,744  Stockholders’ equity (1) 19,078  19,246  Total liabilities and stockholders’ equity $ 56,434  $ 58,995  ________________________________ (1)     As of March 31, 2025 and December 31, 2024, there were 1,245 and 1,246 shares of common stock issued and outstanding, respectively. April 24, 2025 13      GILEAD SCIENCES, INC. SELECTED CASH FLOW INFORMATION (unaudited) Three Months Ended March 31, (in millions) 2025 2024 Net cash provided by operating activities $ 1,757  $ 2,219  Net cash used in investing activities (415) (2,207) Net cash used in financing activities (3,426) (1,361) Effect of exchange rate changes on cash and cash equivalents 19  (18) Net change in cash and cash equivalents (2,065) (1,367) Cash and cash equivalents at beginning of period 9,991  6,085  Cash and cash equivalents at end of period $ 7,926  $ 4,718  Three Months Ended March 31, (in millions) 2025 2024 Net cash provided by operating activities $ 1,757  $ 2,219  Purchases of property, plant and equipment (104) (105) Free cash flow (1) $ 1,653  $ 2,114  ________________________________ (1)     Free cash flow is a non-GAAP liquidity measure. Please refer to our disclosures in the Non-GAAP Financial Information section above. April 24, 2025 14      GILEAD SCIENCES, INC. PRODUCT SALES SUMMARY (unaudited) Three Months Ended March 31, (in millions) 2025 2024 HIV Biktarvy – U.S. $ 2,474  $ 2,315  Biktarvy – Europe 375  365  Biktarvy – Rest of World 301  265  3,150  2,946  Descovy – U.S. 538  371  Descovy – Europe 21  26  Descovy – Rest of World 27  29  586  426  Genvoya – U.S. 305  332  Genvoya – Europe 40  49  Genvoya – Rest of World 19  21  364  403  Odefsey – U.S. 215  223  Odefsey – Europe 57  76  Odefsey – Rest of World 10  11  281  310  Symtuza - Revenue share (1) – U.S. 82  104  Symtuza - Revenue share (1) – Europe 29  33  Symtuza - Revenue share (1) – Rest of World 3  3  114  141  Other HIV (2) – U.S. 50  60  Other HIV (2) – Europe 31  45  Other HIV (2) – Rest of World 10  12  91  117  Total HIV – U.S. 3,664  3,405  Total HIV – Europe 553  596  Total HIV – Rest of World 370  342  4,587  4,342  Liver Disease Sofosbuvir / Velpatasvir (3) – U.S. 166  248  Sofosbuvir / Velpatasvir (3) – Europe 80  79  Sofosbuvir / Velpatasvir (3) – Rest of World 99  78  346  405  Vemlidy – U.S. 100  95  Vemlidy – Europe 12  11  Vemlidy – Rest of World 140  119  252  225  Other Liver Disease (4) – U.S. 68  42  Other Liver Disease (4) – Europe 76  47  Other Liver Disease (4) – Rest of World 17  19  161  107  Total Liver Disease – U.S. 335  385  Total Liver Disease – Europe 168  137  Total Liver Disease – Rest of World 256  215  758  737  Veklury Veklury – U.S. 199  315  Veklury – Europe 22  70  Veklury – Rest of World 82  169  302  555  April 24, 2025 15      GILEAD SCIENCES, INC. PRODUCT SALES SUMMARY - (Continued) (unaudited) Three Months Ended March 31, (in millions) 2025 2024 Oncology Cell Therapy Tecartus – U.S. 40  55  Tecartus – Europe 31  36  Tecartus – Rest of World 8  8  78  100  Yescarta – U.S. 160  170  Yescarta – Europe 149  158  Yescarta – Rest of World 77  52  386  380  Total Cell Therapy – U.S. 200  225  Total Cell Therapy – Europe 180  195  Total Cell Therapy – Rest of World 84  60  464  480  Trodelvy Trodelvy – U.S. 181  206  Trodelvy – Europe 75  68  Trodelvy – Rest of World 37  36  293  309  Total Oncology – U.S. 381  431  Total Oncology – Europe 255  262  Total Oncology – Rest of World 121  96  757  789  Other AmBisome – U.S. 5  14  AmBisome – Europe 67  70  AmBisome – Rest of World 66  60  139  144  Other (5) – U.S. 47  59  Other (5) – Europe 9  9  Other (5) – Rest of World 14  12  70  80  Total Other – U.S. 52  73  Total Other – Europe 76  79  Total Other – Rest of World 81  71  209  224  Total product sales – U.S. 4,631  4,609  Total product sales – Europe 1,073  1,144  Total product sales – Rest of World 909  894  $ 6,613  $ 6,647  ________________________________ (1)     Represents Gilead’s revenue from cobicistat (“C”), FTC and TAF in Symtuza (darunavir/C/FTC/TAF), a fixed dose combination product commercialized by Janssen Sciences Ireland Unlimited Company. (2)     Includes Atripla, Complera/Eviplera, Emtriva, Sunlenca, Stribild, Truvada and Tybost. (3)     Includes Epclusa and the authorized generic version of Epclusa sold by Gilead’s separate subsidiary, Asegua Therapeutics LLC (“Asegua”). (4)     Includes ledipasvir/sofosbuvir (Harvoni and the authorized generic version of Harvoni sold by Asegua), Hepcludex, Hepsera, Livdelzi/Lyvdelzi, Sovaldi, Viread and Vosevi. (5)     Includes Cayston, Jyseleca, Letairis and Zydelig.