| Metric | Oct 29, 2024 FY24 Q3 | Feb 10, 2025 FY24 Q4 | Apr 29, 2025 FY25 Q1 | Jul 29, 2025 FY25 Q2 | Oct 28, 2025 FY25 Q3 | Feb 10, 2026 FY25 Q4 | Apr 28, 2026 FY26 Q1 | Jul 28, 2026 FY26 Q2 |
|---|---|---|---|---|---|---|---|---|
| For FY2030 | ||||||||
| Goal for impactful product launches | — | New“more than 10” | — | — | — | — | — | — |
| High impact launches | — | — | New“more than 10” | — | — | — | — | — |
| For FY2026 | ||||||||
| Estimated impact on third and fourth quarters of 2026 net sales from improved GTN | — | — | — | — | — | — | — | New“$40 - $50 million” |
| Hematology and Oncology net product revenue (1) | — | — | — | — | — | New“$800 - $880 million” | — | — |
| Hematology and Oncology net sales | — | — | — | — | — | — | — | New“$860 - $890 million” |
| Hematology and Oncology net sales (3) | — | — | — | — | — | — | New“$800 - $880 million” | — |
| Jakafi net product revenue | — | — | — | — | — | New“$3,220 to $3,270 million” | — | — |
| Jakafi net sales (1) | — | — | — | — | — | — | New“$3,220 - $3,270 million” | — |
| Opzelura net product revenue | — | — | — | — | — | New“$750 to $790 million” | — | — |
| Opzelura net sales | — | — | — | — | — | — | — | New“$1,050 - $1,100 million” |
| Opzelura net sales (2) | — | — | — | — | — | — | New“$750 - $790 million” | — |
| Total estimated incremental impact on Opzelura net sales for the full year 2026 | — | — | — | — | — | — | — | New“$300 - $310 million” |
| Total net product revenue | — | — | — | — | — | New“$4,770 to $4,940 million” | — | — |
| Total net sales | — | — | — | — | — | — | — | New“$5,130 - $5,260 million” |
| Total net sales | — | — | — | — | — | — | New“$4,770 - $4,940 million” | — |
| IPR&D expense | — | — | — | — | — | — | — | New“approximately $1,270 million” |
| IPR&D expense associated with Vega Therapeutics acquisition | — | — | — | — | — | — | — | New“approximately $1,270 million” |
| Total GAAP R&D and SG&A operating expense | — | — | — | — | — | New“$3,495 to $3,675 million” | — | Raised“$4,915 - $4,995 million” |
| Total GAAP R&D and SG&A operating expenses | — | — | — | — | — | — | New“$3,495 - $3,675 million” | — |
| Total non-GAAP R&D and SG&A operating expense | — | — | — | — | — | — | — | New“$4,625 - $4,695 million” |
| Total non-GAAP R&D and SG&A operating expenses (2) | — | — | — | — | — | New“$3,205 - $3,375 million” | — | — |
| Total Non-GAAP R&D and SG&A operating expenses (4) | — | — | — | — | — | — | New“$3,205 - $3,375 million” | — |
| For FY2025 | ||||||||
| GAAP Cost of product revenues | — | New“8.5% - 9.0% of net product revenues” | Reiterated“8.5% - 9.0% of net product revenues” | Widened“8.0% - 9.0% of net product revenues” | Reiterated“8.0% - 9.0% of net product revenues” | — | — | — |
| Jakafi net product revenue | — | — | — | — | New“$3.050 - $3.075 billion” | — | — | — |
| Jakafi net product revenues | — | — | — | New“$3,000 - $3,050 million” | Raised“$3,050 - $3,075 million” | — | — | — |
| Jakafi net product revenues (raised full year 2025) | — | — | New“$2,950 - $3,000 million” | — | — | — | — | — |
| Jakafi net revenues | — | New“$2,925 - $2,975 million” | — | — | — | — | — | — |
| Net product revenue | — | — | — | — | New“$4.23 - $4.32 billion” | — | — | — |
| Non-GAAP Cost of product revenues | — | New“7.5% - 8.0% of net product revenues” | Reiterated“7.5% - 8.0% of net product revenues” | Widened“7.0% - 8.0% of net product revenues” | — | — | — | — |
| Non-GAAP Cost of product revenues (2) | — | — | — | — | New“7.0% - 8.0% of net product revenues” | — | — | — |
| Opzelura ® (ruxolitinib) cream revenue | — | — | — | — | New“$630 - $670 million” | — | — | — |
| Opzelura net product revenues | — | — | New“$630 - $670 million” | — | Reiterated“$630 - $670 million” | — | — | — |
| Opzelura net revenues | — | New“$630 - $670 million” | — | — | — | — | — | — |
| Other hematology and oncology marketed products revenue | — | — | — | — | New“$550 - $575 million” | — | — | — |
| Other oncology net product revenues | — | New“$415 - $455 million” | Reiterated“$415 - $455 million” | Raised“$500 - $520 million” | — | — | — | — |
| Other oncology net product revenues (1) | — | — | — | — | New“$550 - $575 million” | — | — | — |
| GAAP Research and development expenses | — | New“$1,930 - $1,960 million” | Reiterated“$1,930 - $1,960 million” | Raised“$1,965 - $1,995 million” | Reiterated“$1,965 - $1,995 million” | — | — | — |
| GAAP Selling, general and administrative expenses | — | New“$1,280 - $1,310 million” | Reiterated“$1,280 - $1,310 million” | — | Reiterated“$1,280 - $1,310 million” | — | — | — |
| Jakafi | — | — | — | — | New“$3.050 - $3.075 billion” | — | — | — |
| Jakafi | — | — | — | New“$3,000 - $3,050 million” | — | — | — | — |
| Non-GAAP Research and development expenses | — | New“$1,780 - $1,805 million” | Reiterated“$1,780 - $1,805 million” | Raised“$1,815 - $1,840 million” | — | — | — | — |
| Non-GAAP Research and development expenses (3) | — | — | — | — | New“$1,815 - $1,840 million” | — | — | — |
| Non-GAAP Selling, general and administrative expenses | — | New“$1,160 - $1,185 million” | Reiterated“$1,160 - $1,185 million” | — | — | — | — | — |
| Non-GAAP Selling, general and administrative expenses (3) | — | — | — | — | New“$1,160 - $1,185 million” | — | — | — |
| Other Oncology | — | — | — | New“$500 - $520 million” | — | — | — | — |
| For FY2024 | ||||||||
| Jakafi net product revenues (raised) | New“$2,740 - $2,770 million” | — | — | — | — | — | — | — |
| Non-GAAP Cost of product revenues (2) | New“Unchanged” | — | — | — | — | — | — | — |
| Other Hematology/Oncology net product revenues (1) | New“$310 - $320 million” | — | — | — | — | — | — | — |
| GAAP Research and development expenses | New“$2,545 - $2,590 million” | — | — | — | — | — | — | — |
| Jakafi | New“$2,740 - $2,770 million” | — | — | — | — | — | — | — |
| Non-GAAP Research and development expenses (3) | New“$2,395 - $2,435 million” | — | — | — | — | — | — | — |
| Non-GAAP Selling, general and administrative expenses (3) | New“Unchanged” | — | — | — | — | — | — | — |
| Research and development one-time expenses included | New“$791 million” | — | — | — | — | — | — | — |
| No period stated | ||||||||
| Incremental ongoing R&D investments related to the development of latarcibart | — | — | — | — | — | — | — | New“$50 million” |