Ionis Pharmaceuticals — Apr 30, 2025 release

al results - Encouraging start to first independent launch with TRYNGOLZA TM -   - On track for second independent launch with donidalorsen PDUFA August 21, 2025 -   - Increasing 2025 financial guidance by more than 20% -   CARLSBAD, Calif., April 30, 2025 – Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (the “Company”) today reported financial results for the first quarter ended March 31, 2025 .   “With an encouraging start to the TRYNGOLZA launch for familial chylomicronemia syndrome, the first of four independent launches expected over the next two years, Ionis’ new chapter as a fully integrated, commercial-stage biotechnology company is well underway,” said Brett P. Monia, Ph.D., chief executive officer, Ionis. “We look forward to continued momentum this year, including our second independent launch for donidalorsen in hereditary angioedema and Phase 3 results for olezarsen for severe hypertriglyceridemia in the third quarter. We also continue to advance our next wave of wholly owned neurology medicines, including ION582 for Angelman syndrome, which is on track to start Phase 3 development shortly. Our advancing pipeline of transformational medicines, together with strong commercial and financial execution, position Ionis to deliver increasing value for all stakeholders.”   First Quarter 2025 Summary Financial Results (1) :       Three months ended March 31 ,