| Metric | Nov 7, 2024 FY24 Q3 | Jan 13, 2025 FY24 Q4 | May 1, 2025 FY25 Q1 | Aug 1, 2025 FY25 Q2 | Nov 6, 2025 FY25 Q3 | Jan 12, 2026 FY25 Q4 | May 1, 2026 FY26 Q1 | Jul 31, 2026 FY26 Q2 |
|---|---|---|---|---|---|---|---|---|
| For FY2028 | ||||||||
| Cash breakeven | — | — | — | — | — | New“targeted cash breakeven” | — | — |
| Cost reduction / breakeven target | — | New“breakeven in 2028” | — | — | — | — | — | — |
| For FY2027 | ||||||||
| GAAP operating cost estimate | — | — | New“$4.7 to $5.0 billion” | — | — | — | — | — |
| GAAP operating expenses | — | — | — | — | — | New“$4.2 – $4.6 billion” | — | — |
| Reduction in estimated GAAP operating costs | — | — | New“$1.4 to $1.7 billion” | — | — | — | — | — |
| For FY2026 | ||||||||
| Revenue geographic split | — | — | — | — | — | — | New“approximately 50% U.S. and approximately 50% international” | — |
| Revenue growth | — | — | — | — | — | — | New“up to 10% growth from 2025 revenue” | Reiterated“up to 10% growth from 2025 revenue” |
| Revenue growth target | — | — | — | — | — | New“up to 10%” | — | — |
| Revenue split | — | — | — | — | — | — | — | New“approximately 50% U.S. and approximately 50% international” |
| Revenue split - international | — | — | — | — | — | — | — | New“approximately 50%” |
| Revenue split - International | — | — | — | — | — | — | New“approximately 50%” | — |
| Revenue split - U.S. | — | — | — | — | — | — | New“approximately 50%” | — |
| Second half 2026 revenue recognized | — | — | — | — | — | — | — | New“approximately 55%” |
| Share of second half 2026 revenue recognized in the third quarter | — | — | — | — | — | — | — | New“approximately 55%” |
| Additional 2026 cost reductions | — | New“$0.5 billion” | — | — | — | — | — | — |
| Additional cash cost savings | — | New“$0.5 billion” | — | — | — | — | — | — |
| Capital expenditures | — | — | — | — | — | — | New“$0.2 to $0.3 billion” | Reiterated“$0.2 to $0.3 billion” |
| Cost of sales | — | — | — | — | — | — | New“approximately $1.8 billion, including the $0.9 billion non-recurring litigation settlement charge” | Lowered“approximately $1.7 billion” |
| Estimated GAAP operating costs | — | — | New“$5.4 to $5.7 billion” | — | — | — | — | — |
| GAAP operating expenses | — | — | — | — | — | New“approximately $4.9 billion” | — | — |
| Income Taxes | — | — | — | — | — | — | New“full-year tax expense to be negligible” | Revised“negligible” |
| Litigation settlement payment | — | — | — | — | — | — | New“$950 million” | — |
| Research and development expenses | — | — | — | — | — | — | New“approximately $3.0 billion” | Lowered“approximately $2.9 billion” |
| Selling, general and administrative expenses | — | — | — | — | — | — | New“approximately $1.0 billion” | Reiterated“approximately $1.0 billion” |
| Tax expense | — | — | — | — | — | — | New“negligible” | Reiterated“negligible” |
| Year-end cash and investments | — | — | — | — | — | — | New“$4.5 to $5.0 billion” | Raised“$4.7 to $5.2 billion” |
| For FY2025 | ||||||||
| Expected revenue | — | — | New“$1.5 to $2.5 billion” | — | — | — | — | — |
| Expected revenue range | — | New“$1.5 to 2.5 billion” | — | — | — | — | — | — |
| First half 2025 revenue | — | — | New“approximately $0.2 billion” | — | — | — | — | — |
| Projected revenue range | — | — | — | New“$1.5 to $2.2 billion” | Narrowed“$1.6 to $2.0 billion” | — | — | — |
| Revenue | — | New“$1.5 to 2.5 billion” | Reiterated“$1.5 to $2.5 billion” | — | Narrowed“$1.6 to $2.0 billion” | — | — | — |
| Revenue | — | — | — | New“$1.5 to $2.2 billion” | — | — | — | — |
| Revenue | — | — | New“approximately $0.2 billion” | — | — | — | — | — |
| Revenue split | — | — | — | New“40-50% in the third quarter with the balance in the fourth quarter of 2025” | — | — | — | — |
| Revenue split | — | — | — | New“40-50%” | — | — | — | — |
| Second half 2025 revenue split | — | — | — | New“40-50% in the third quarter with the balance in the fourth quarter” | — | — | — | — |
| Capital expenditures | — | — | — | New“approximately $0.3 billion” | Reiterated“approximately $0.3 billion” | — | — | — |
| Capital expenditures | — | — | New“approximately $0.4 billion” | — | — | — | — | — |
| Cash cost expenses reduction | — | New“$1.0 billion” | — | — | — | — | — | — |
| Cost of sales | — | — | — | New“approximately $1.2 billion” | Lowered“approximately $0.8 to $0.9 billion” | — | — | — |
| Cost of sales | — | — | New“approximately $1.2 billion” | — | — | — | — | — |
| Expected ending cash balance | — | New“approximately $6.0 billion” | — | — | — | — | — | — |
| Expected GAAP operating expenses | — | — | — | New“$5.9 to $6.1 billion” | Lowered“$5.2 - $5.4 billion” | — | — | — |
| Expected year-end cash balance | — | — | — | New“approximately $6 billion” | — | — | — | — |
| Full-year tax expense | — | — | New“negligible” | — | — | — | — | — |
| GAAP operating expenses | — | — | — | — | — | New“$5.0 – $5.2 billion (unaudited)” | — | — |
| Income Taxes | — | — | New“negligible” | Reiterated“negligible” | Reiterated“negligible” | — | — | — |
| Potential product approvals | — | New“up to three potential 2025 approvals” | — | — | — | — | — | — |
| Projected year-end cash balance | — | — | — | — | — | New“approximately $8.1 billion (unaudited)” | — | — |
| Research and development expenses | — | — | — | — | New“$3.3 to $3.4 billion” | — | — | — |
| Research and development expenses | — | — | New“approximately $4.1 billion” | Lowered“$3.6 to $3.8 billion” | — | — | — | — |
| Selling, general and administrative expenses | — | — | — | New“approximately $1.1 billion” | Reiterated“approximately $1.1 billion” | — | — | — |
| Selling, general and administrative expenses | — | — | New“approximately $1.1 billion” | — | — | — | — | — |
| Tax expense | — | — | — | New“negligible” | Reiterated“negligible” | — | — | — |
| Total headcount | — | — | — | New“under 5,000” | — | — | — | — |
| Year-end cash and investments | — | — | — | New“approximately $6 billion” | Raised“$6.5 to $7 billion” | — | — | — |
| Year-end cash and investments for 2025 | — | — | New“approximately $6 billion” | — | — | — | — | — |
| For FY2024 | ||||||||
| Net Sales | New“$3.0 to $3.5 billion” | — | — | — | — | — | — | — |
| Capital expenditures | New“approximately $1.2 billion” | — | — | — | — | — | — | — |
| Cost of Sales | New“40-45%” | — | — | — | — | — | — | — |
| Income Taxes | New“negligible” | — | — | — | — | — | — | — |
| Net product sales from its respiratory franchise | New“$3.0 to $3.5 billion” | — | — | — | — | — | — | — |
| Research and development expenses | New“$4.6 to $4.7 billion” | — | — | — | — | — | — | — |
| Selling, general and administrative expenses | New“approximately $1.2 billion” | — | — | — | — | — | — | — |
| Tax expense | New“negligible” | — | — | — | — | — | — | — |
| Year-end cash and investments | New“approximately $9 billion” | — | — | — | — | — | — | — |
| No period stated | ||||||||
| Cost of sales | New“40-45% of product sales” | — | — | — | — | — | — | — |
| Prioritized programs with anticipated milestones | — | New“10” | — | — | — | — | — | — |
| Product Approvals | New“10” | — | — | — | — | — | — | — |
| Product approvals target | — | New“up to 10 product approvals over the next three years” | — | — | — | — | — | — |
| Products advancing toward approval | — | — | New“up to 10” | — | — | — | — | — |
| Registrational data readouts | — | New“six” | — | — | — | — | — | — |