Current guidance
42 items
Each item compared with the same item in the previous release (May 4, 2026). Values in quotation marks are the company’s words.
| Change | Metric | Period | Previous | Now | Source |
|---|---|---|---|---|---|
| New | Peak revenue for GALAFOLD | for FY2030 | — | “approximately $1.4 billion” | Filing ↗ |
| New | Peak revenue for POMBILITI + OPFOLDA | for FY2030 | — | “approximately $1.2 billion” | Filing ↗ |
| New | Metabolic Conditions Revenue | for FY2026 | — | “Unchanged” | Filing ↗ |
| Narrowed | Total Revenues | for FY2026 | “$3,825 to $3,925” | “$3,875 to $3,925” | Filing ↗ |
| New | Total Revenues Midpoint Growth (Y/Y) | for FY2026 | — | “21%” | Filing ↗ |
| New | VOXZOGO full-year 2026 revenue (CEO quote) | for FY2026 | — | “at least $1 billion” | Filing ↗ |
| New | VOXZOGO Revenue | for FY2026 | — | “$1,000 to $1,050” | Filing ↗ |
| New | GALAFOLD and POMBILITI + OPFOLDA, combined, Non-GAAP Operating Margin | for FY2030 | — | “over 60%” | Filing ↗ |
| New | Combined company tax rate assumption for Non-GAAP Diluted EPS | for FY2026 | — | “22%” | Filing ↗ |
| Raised | Non-GAAP Diluted EPS | for FY2026 | “$4.85 to $5.05” | “$4.90 to $5.10” | Filing ↗ |
| New | Non-GAAP Diluted EPS Midpoint Growth (Y/Y) | for FY2026 | — | “59%” | Filing ↗ |
| New | Weighted-Average Diluted Shares Outstanding assumption for Non-GAAP Diluted EPS | for FY2026 | — | “approximately 200 million” | Filing ↗ |
| New | Cost reductions from Amicus acquisition (GAAP basis) | for FY2028 | — | “approximately $280 million” | Filing ↗ |
| New | Cost reductions from Amicus acquisition (Non-GAAP basis) | for FY2028 | — | “approximately $220 million” | Filing ↗ |
| New | Cost reductions on a GAAP basis | for FY2028 | — | “approximately $280 million” | Filing ↗ |
| New | Gross leverage target | for FY2027 | — | “below 2.5 times” | Filing ↗ |
| New | Metabolic Conditions | for FY2026 | — | “$2,725 to $2,775” | Filing ↗ |
| New | Metabolic Conditions Midpoint Growth (Y/Y) | for FY2026 | — | “31%” | Filing ↗ |
| New | VOXZOGO Midpoint Growth (Y/Y) | for FY2026 | — | “11%” | Filing ↗ |
| Reiterated | Other Revenues | for FY2026 | “$100 to $125” | “$100 to $125” | Filing ↗ |
| Change | Metric | Period | Previous | Now | Source |
|---|---|---|---|---|---|
| Not restated | Total revenues CAGR | for FY2034 | “Mid-teen compound annual growth rate (CAGR)” | — | Filing ↗ |
| Not restated | Total revenues compound annual growth rate (CAGR) | for FY2034 | “Mid-teen” | — | Filing ↗ |
| Not restated | PALYNZIQ Revenue | for FY2026 | “expected to increase year-over-year” | — | Filing ↗ |
| Not restated | Total Revenues (Full-Year) | for FY2026 | “between $3.825 billion and $3.925 billion” | — | Filing ↗ |
| Not restated | Treatments for Skeletal Conditions revenue opportunity | No period stated | “greater than $5 billion” | — | Filing ↗ |
| Not restated | Amicus Acquisition Impact on Non-GAAP Diluted EPS | for FY2026 | “slightly dilutive” | — | Filing ↗ |
| Not restated | Non-GAAP Diluted EPS Recognized in Second Half of 2026 | for H2 FY2026 | “approximately two-thirds” | — | Filing ↗ |
| Not restated | Non-GAAP Operating Margin | for FY2026 | “40%” | — | Filing ↗ |
| Not restated | Non-GAAP Operating Margin | No period stated | “low- to mid-40% range” | — | Filing ↗ |
| Not restated | Enzyme Therapies long-term growth outlook (CAGR) | for the long term | “high single-digit CAGR” | — | Filing ↗ |
Guidance for periods that have not yet ended, at its most recent value, grouped by horizon.
| Metric | Current value | Period | Measure | First stated | Times stated | Source |
|---|---|---|---|---|---|---|
| Metabolic Conditions Revenue | “Unchanged” | for FY2026 | GAAP-tied | Aug 6, 2026 | 1 | Filing ↗ |
| Other Revenues | “$100 to $125” | for FY2026 | GAAP-tied | May 4, 2026 | 2 | Filing ↗ |
| PALYNZIQ Revenue | “expected to increase year-over-year” | for FY2026 | GAAP-tied | May 4, 2026 | 1 | Filing ↗ |
| ROCTAVIAN revenue treatment in 2026 | “ROCTAVIAN revenue to be excluded from 2026 guidance” | for FY2026 | GAAP-tied | Jan 12, 2026 | 1 | Filing ↗ |
| Total Revenues | “$3,875 to $3,925” | for FY2026 | GAAP-tied | May 4, 2026 | 2 | Filing ↗ |
| Total Revenues (Full-Year) | “between $3.825 billion and $3.925 billion” | for FY2026 | GAAP-tied | May 4, 2026 | 1 | Filing ↗ |
| Total Revenues Expected in Second Half of 2026 | “more than 55%” | for H2 FY2026 | GAAP-tied | May 4, 2026 | 1 | Filing ↗ |
| Total Revenues Growth Rate (Y/Y, at Midpoint) | “20%” | for FY2026 | GAAP-tied | May 4, 2026 | 1 | Filing ↗ |
| Total Revenues Midpoint Growth (Y/Y) | “21%” | for FY2026 | GAAP-tied | Aug 6, 2026 | 1 | Filing ↗ |
| VOXZOGO full-year 2026 revenue (CEO quote) | “at least $1 billion” | for FY2026 | GAAP-tied | Aug 6, 2026 | 1 | Filing ↗ |
| VOXZOGO Revenue | “$1,000 to $1,050” | for FY2026 | GAAP-tied | Aug 6, 2026 | 1 | Filing ↗ |
| Amicus Acquisition Impact on Non-GAAP Diluted EPS | “slightly dilutive” | for FY2026 | Company-defined | May 4, 2026 | 1 | Filing ↗ |
| Combined company tax rate assumption for Non-GAAP Diluted EPS | “22%” | for FY2026 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Non-GAAP Diluted EPS | “$4.90 to $5.10” | for FY2026 | Company-defined | May 4, 2026 | 2 | Filing ↗ |
| Non-GAAP Diluted EPS - combined company tax rate assumption | “22%” | for FY2026 | Company-defined | May 4, 2026 | 1 | Filing ↗ |
| Non-GAAP Diluted EPS - Weighted-Average Diluted Shares Outstanding assumption | “approximately 200 million” | for FY2026 | Company-defined | May 4, 2026 | 1 | Filing ↗ |
| Non-GAAP Diluted EPS Midpoint Growth (Y/Y) | “59%” | for FY2026 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Non-GAAP Diluted EPS Recognized in Second Half of 2026 | “approximately two-thirds” | for H2 FY2026 | Company-defined | May 4, 2026 | 1 | Filing ↗ |
| Non-GAAP Operating Margin | “40%” | for FY2026 | Company-defined | Oct 29, 2024 | 2 | Filing ↗ |
| Weighted-Average Diluted Shares Outstanding assumption for Non-GAAP Diluted EPS | “approximately 200 million” | for FY2026 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Enzyme Therapies | “$2,725 to $2,775” | for FY2026 | Company-defined | May 4, 2026 | 1 | Filing ↗ |
| Metabolic Conditions | “$2,725 to $2,775” | for FY2026 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Metabolic Conditions Midpoint Growth (Y/Y) | “31%” | for FY2026 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| VOXZOGO | “$975 to $1,025” | for FY2026 | Company-defined | May 4, 2026 | 1 | Filing ↗ |
| VOXZOGO Midpoint Growth (Y/Y) | “11%” | for FY2026 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Metric | Current value | Period | Measure | First stated | Times stated | Source |
|---|---|---|---|---|---|---|
| Total revenues CAGR | “Mid-teen compound annual growth rate (CAGR)” | for FY2034 | GAAP-tied | Oct 29, 2024 | 1 | Filing ↗ |
| Total revenues compound annual growth rate (CAGR) | “Mid-teen” | for FY2034 | GAAP-tied | Oct 29, 2024 | 1 | Filing ↗ |
| Peak revenue for GALAFOLD | “approximately $1.4 billion” | for FY2030 | GAAP-tied | Aug 6, 2026 | 1 | Filing ↗ |
| Peak revenue for POMBILITI + OPFOLDA | “approximately $1.2 billion” | for FY2030 | GAAP-tied | Aug 6, 2026 | 1 | Filing ↗ |
| Total Revenues | “approximately $4 billion” | for FY2027 | GAAP-tied | Oct 29, 2024 | 2 | Filing ↗ |
| GALAFOLD and POMBILITI + OPFOLDA, combined, Non-GAAP Operating Margin | “over 60%” | for FY2030 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| BMN 333 achondroplasia approval target | “2030” | for FY2030 | Company-defined | May 1, 2025 | 1 | Filing ↗ |
| Cost reductions from Amicus acquisition (GAAP basis) | “approximately $280 million” | for FY2028 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Cost reductions from Amicus acquisition (Non-GAAP basis) | “approximately $220 million” | for FY2028 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Cost reductions on a GAAP basis | “approximately $280 million” | for FY2028 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Gross leverage target | “below 2.5 times” | for FY2027 | Company-defined | Aug 6, 2026 | 1 | Filing ↗ |
| Operating cash flow | “More than $1.25 billion” | for FY2027 | GAAP-tied | Oct 29, 2024 | 1 | Filing ↗ |
| Operating cash flows | “more than $1.25 billion” | for FY2027 | GAAP-tied | Feb 19, 2025 | 1 | Filing ↗ |
| VOXZOGO country access expansion | “more than 20 additional countries” | for FY2027 | Company-defined | Oct 29, 2024 | 1 | Filing ↗ |
| VOXZOGO country access target | “more than 60 countries” | for FY2027 | Company-defined | Aug 4, 2025 | 1 | Filing ↗ |
| VOXZOGO country availability | “more than 60 countries” | for FY2027 | Company-defined | Feb 19, 2025 | 1 | Filing ↗ |
| Metric | Current value | Period | Measure | First stated | Times stated | Source |
|---|---|---|---|---|---|---|
| Enzyme Therapies long-term growth outlook (CAGR) | “high single-digit CAGR” | for the long term | Company-defined | Feb 19, 2025 | 1 | Filing ↗ |
Total Revenues, for FY2026 — every statement across the year, each linked to its filing.
12 companies in Biopharma. What they guide on, and who reported this season.
| BioMarin Pharmaceutical | Aug 6, 2026 | 19 changes |
| Halozyme Therapeutics | Aug 6, 2026 | 6 changes |
| Eli Lilly | Aug 5, 2026 | 5 changes |
| Amgen | Aug 4, 2026 | 5 changes |
| Gilead Sciences | Aug 4, 2026 | 15 changes |
| Moderna | Jul 31, 2026 | 8 changes |
| Neurocrine Biosciences | Jul 30, 2026 | 16 changes |
| Regeneron Pharmaceuticals | Jul 30, 2026 | 22 changes |
Every metric, every release, eight quarters — the complete record as one table.
| Metric | FY2034 | FY2030 | FY2028 | FY2027 | FY2026 | FY2025 | FY2024 | FY2023 | Long-term | No period |
|---|---|---|---|---|---|---|---|---|---|---|
| Metabolic Conditions Revenue | — | — | — | — | 1 statement | — | — | — | — | — |
| Other Revenues | — | — | — | — | 2 statements | — | — | — | — | — |
| PALYNZIQ Revenue | — | — | — | — | 1 statement | — | — | — | — | — |
| Peak revenue for GALAFOLD | — | 1 statement | — | — | — | — | — | — | — | — |
| Peak revenue for POMBILITI + OPFOLDA | — | 1 statement | — | — | — | — | — | — | — | — |
The 8 earnings releases this page is built from.
| Filed | Fiscal period | Accession | Guidance items | |
|---|---|---|---|---|
| Aug 6, 2026 | FY2026 Q2 | 0001048477-26-000015 | 22 | Open filing ↗ |
| May 4, 2026 | FY2026 Q1 | 0001048477-26-000006 | 14 | Open filing ↗ |
| Jan 12, 2026 | FY2025 Q4 | 0001193125-26-010508 | 8 | Open filing ↗ |
| Oct 7, 2025 | FY2025 Q3 | 0001048477-25-000101 | 3 | Open filing ↗ |
| Aug 4, 2025 | FY2025 Q2 | 0001048477-25-000088 | 9 | Open filing ↗ |
| May 1, 2025 | FY2025 Q1 | 0001048477-25-000049 | 6 | Open filing ↗ |
| Feb 19, 2025 | FY2024 Q4 | 0001048477-25-000004 | 14 | Open filing ↗ |
| Oct 29, 2024 | FY2024 Q3 | 0001048477-24-000149 | 12 | Open filing ↗ |