Incyte — Jul 29, 2025 release

Furthermore, Incyte is updating its expense guidance for research and development to reflect the increase due to upfront and ongoing expenses related to new collaborations with Genesis and Biotheryx. Current Previous Jakafi net product revenues $3,000 - $3,050 million $2,950 - $3,000 million Opzelura net product revenues Unchanged $630 - $670 million Other oncology net product revenues (1) $500 - $520 million $415 - $455 million GAAP Cost of product revenues 8.0% - 9.0% of net product revenues 8.5% - 9.0% of net product revenues Non-GAAP Cost of product revenues (2) 7.0% - 8.0% of net product revenues 7.5% - 8.0% of net product revenues GAAP Research and development expenses $1,965 - $1,995 million $1,930 - $1,960 million Non-GAAP Research and development expenses (3) $1,815 - $1,840 million $1,780 - $1,805 million GAAP Selling, general and administrative expenses Unchanged $1,280 - $1,310 million Non-GAAP Selling, general and administrative expenses (3) Unchanged $1,160 - $1,185 million 1 Pemazyre in the U.S., EU and Japan; Niktimvo, Monjuvi and Zynyz in the U.S.; and Iclusig and Minjuvi in the EU. 2 Adjusted to exclude the amortization of licensed intellectual property for Iclusig relating to the acquisition of the European business of ARIAD Pharmaceuticals, Inc. and the estimated cost of stock-based compensation. 3 Adjusted to exclude the estimated cost of stock-based compensation. Conference Call and Webcast Information Incyte will hold a conference call and webcast this morning at 8:00 a.m. ET. To access the conference call, please dial 877-407-3042 for domestic callers or 201-389