| Metric | Nov 6, 2024 FY24 Q3 | Feb 19, 2025 FY24 Q4 | Apr 30, 2025 FY25 Q1 | Jul 30, 2025 FY25 Q2 | Oct 29, 2025 FY25 Q3 | Jan 12, 2026 FY25 Q4 | Apr 29, 2026 FY26 Q1 | Jul 29, 2026 FY26 Q2 |
|---|---|---|---|---|---|---|---|---|
| For FY2028 | ||||||||
| Cash flow breakeven | — | — | — | — | New“achieve cash flow breakeven in 2028” | — | — | — |
| Cash flow breakeven target | — | — | — | — | — | New“achieve cash flow breakeven in 2028” | — | — |
| Cashflow breakeven goal | — | — | — | — | — | — | — | New“cashflow breakeven in 2028” |
| Goal of reaching cash-flow breakeven | — | — | — | — | — | — | New“cash-flow breakeven in 2028” | — |
| For FY2026 | ||||||||
| Annual olezarsen peak net sales | — | — | — | — | — | — | New“>$3 billion” | — |
| Total Revenue | — | — | — | — | — | — | New“$875-900 million” | — |
| Cash, cash equivalents and short-term investments | — | — | — | — | — | — | New“>$1.6 billion” | — |
| DAWNZERA full year 2026 product sales | — | — | — | — | — | — | — | New“$110-120 million” |
| DAWNZERA product sales, net | — | — | — | — | — | — | New“$110-120 million” | — |
| Operating expense growth | — | — | — | — | — | — | — | New“low-teens percentage growth year-over-year” |
| Operating loss on a non-GAAP basis | — | — | — | — | — | — | New“$425-475 million” | — |
| TRYNGOLZA full year 2026 product sales | — | — | — | — | — | — | — | New“$100-110 million” |
| TRYNGOLZA product sales, net | — | — | — | — | — | — | New“$100-110 million” | — |
| For FY2025 | ||||||||
| Revenue | — | — | New“$725-750 million” | — | — | — | — | — |
| Total Revenue | — | — | — | New“$825 - 850 million” | Raised“$875-900 million” | — | — | — |
| TRYNGOLZA (olezarsen) annual peak net sales for sHTG | — | — | — | — | — | New“>$2B” | — | — |
| Cash, cash equivalents and short-term investments | — | New“~$1.7 billion” | — | Raised“~$2.0 billion” | Raised“>$2.1 billion” | — | — | — |
| Cash, cash equivalents and short-term investments (year-end expectation) | — | — | New“approximately $1.9 billion” | — | — | — | — | — |
| Financial increase | — | — | New“by more than 20%” | — | — | — | — | — |
| Operating loss on a non-GAAP basis | — | New“<$495 million” | Lowered“<$375 million” | — | — | — | — | — |
| TRYNGOLZA product sales, net | — | — | — | New“$75-80 million” | Raised“$85-95 million” | — | — | — |
| For FY2024 | ||||||||
| Cash | New“$2.2 billion” | — | — | — | — | — | — | — |
| Cash, cash equivalents and short-term investments (year-end projection) | New“$2.2 billion” | — | — | — | — | — | — | — |
| No period stated | ||||||||
| Olezarsen peak net sales | — | — | — | — | — | New“Increasing annual olezarsen peak net sales guidance to >$2 billion from >$1 billion based on strong product profile and positive Phase 3 data” | — | — |